Are Heat Shock Proteins Druggable Candidates?
نویسندگان
چکیده
منابع مشابه
HDAC Inhibitors and Heat Shock Proteins (Hsps)
Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
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As all biologists appreciate, there is constant interaction between life and the environment, and temperature plays a critical role. It establishes distribution limits, it affects rates of function as well as the survival of organisms. Notoriously sensitive to temperature is plant growth. Critical steps in plant life such as germination, flowering and breaking of dormancy can be manipulated by ...
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The enhanced synthesis of a few proteins immediately after subjecting cells to a stress such as heat shock was first reported for drosophila cells in 1974 (l), and the universality of the response from bacteria to human was recognized shortly thereafter (reviewed in Ref. 2). In the ensuing 16 years, a vast literature has accumulated that describes a wide variety of events in a cell’s response t...
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PERSPECTIVES ANDUMMARY .............................................................. 632 HSP110 .................................................................................................. 634 THE HSP 90 FAMILY .............................................................................. 634 Biochemical Analysis ..............................................................................
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ژورنال
عنوان ژورنال: American Journal of Biochemistry and Biotechnology
سال: 2014
ISSN: 1553-3468
DOI: 10.3844/ajbbsp.2014.208.210